Complications and hospital outcome of methanol toxicity in patients admitted in Sina Hospital – Tabriz

Abstract

outbreaks of methanol poisoning occur widely in the world and in our country and cause death and debilitating complications. The aim of this investigation is assessing the prognosis and complications of methanol intoxication. The study was carried out on patients in Tabriz Sina hospital from February 20, 2020 till June 20 , 2020. During this period, more than 200 patients admitted to the hospital were investigated and analyzed considering age, gender, the interval between consumption and the emergence of symptoms, the amount of drunk alcohol, vital signs on admission, disease symptoms, lab results, and permanent complications. Methods : This study is a cross-sectional one in which, after obtaining the code of ethics, the required data was extracted from the files of the methanol intoxicated patients hospitalized in Tabriz Sina hospital from February 20, 2020 to the end of June 20, 2020. From the 224 patients, 40 cases were excluded due to concomitant poisoning with other drugs or non-methanol alcohol poisoning. The data of the investigated patients was entered into SPSS26. Chi-Square and Logistic Regression tests were used in this analysis. Results : From the 184 patients, 77.72% (143) recovered completely, 14.67% (27) recovered with permanent complications, and 7.61% (14) died. 92.9% of the patients were male and 7.1% of them were female. The most significant predictors of mortality were an increase in the amount of Basal excess and creatinine and liver enzymes and decrease in respiratory rate, systolic blood pressure and mean arterial pressure and pH and PCO2 on admission and occurance of arrhythmia. Visual symptoms on admission has protective effects against morbidity and mortality.