HPV typing in high-grade intraepithelial lesions and cervical carcinoma; Determining the most common type of high-risk virus as an etiological agent

Abstract

Human papillomavirus (HPV) is an important factor in cervical cancer. There are many types of HPV that can infect a large range of animals and humans. Due to the fact that in our country, and especially in our geographical region, the available studies on the frequency and prevalence of different genotypes of HPV are very limited, so the purpose of this study is to classify HPV in high-grade intraepithelial lesions and cervical carcinoma and determining the most common type of high-risk HPV as an etiological factor. Materials and Methods: A total of 101 patients with a complaint of vaginal bleeding and HPV sampling with a positive sample and HPV typing were included in the study. Data related to demographic information and data related to HPV typing were recorded. Finally, the data were evaluated by SPSS statistical software Results: The mean and standard deviation of age in the patient group was 40.75 ±12 12.06. In the evaluation of intraepithelial lesions in patients, HSIL → Adenocarcinoma (1%) 1, Adenocarcinoma (4%) 4, ASC-H (30.7%) 31, ASC-H → HSIL (2%)2, HSIL (44.6%) was 45, LSIC → HSIL (9.9%) was 10 and SCC (9.7%) was 8. In the evaluation of HPV types in patients, HPV 6 (2%) 2, HPV 11 (1%) 1, HPV 16 (54.5%) 55, HPV 18 (21.8%) 22, HPV 31 (6.9%) 7, HPV 33 (1%) 1, HPV 35 (2%) 2, HPV 43 (1%) 1, HPV 51 (4%) 4, HPV 52 (1%), HPV 53 (2%) 2, HPV 68 (1%) 1 and HPV 73 (1%) 1. Also, the mean and standard deviation of age in the HPV 18 group was 34.90 ± 10.12 and in the non-HPV 18 group was 42.29 ± 12.11, which was statistically significant between the two groups (p = 0.007).