Investigation of the effect of piperine supplement on anthropometric indices, ultrasonographic findings, biochemical parameters and quality of life in patients with nonalcoholic fatty liver disease

Abstract

Considering the high prevalence of fatty liver disease in our society and the increasing number of people suffering from it, and on the other hand, there is no study on the effects of piperine in the treatment of patients with fatty liver, this study aims to investigate the effects of Piperine was designed for patients with non-alcoholic fatty liver disease. Methodology: after approving the plan and obtaining permission from the ethics committee and registering the plan in the clinical trial center, fully explaining the study conditions to the patients and obtaining informed consent, 64 patients with grade 2 and 3 fatty liver based on ultrasonographic findings and ALT blood level More than 1.5 times the maximum normal amount were included in the study in both case and control groups. The intervention group was prescribed piperine capsule with a dose of 5 mg per day as a single dose, which is pepper extract, for 12 weeks, and the control group was given a placebo. The study was double-blind and both the doctor and the patients did not know about the type of drug (piperine capsule or placebo). The investigated variables included the demographic findings of age, gender, height, weight, body mass index, waist circumference, hip circumference, neck circumference, underlying diseases including diabetes, systolic and diastolic hypertension, laboratory findings and ultrasound findings. After collecting the data, the information was analyzed using spss16 software using independent t and paired t statistical tests. Findings: In investigating the effect of piperine on anthropometric indicators, the results showed that there was no statistically significant difference between the two groups after 12 weeks of intervention. ALT(0.000), AST(0.01), TG(0.000), HDL(0.04), LDL(0.01), GGT(0.01), NFS(0.000), Fatty liver index(0.000) and FIB( 0.000) there was a significant difference between the two study groups, so that in the intervention group the level of HDL increased and the other mentioned variables decreased. After the study, there was a significant difference between the two groups in the grade of fatty liver, so that the grade of fatty liver in the intervention group was lower than the control group, which indicates the positive effect of piperine consumption. Using the t-test of two independent groups, there was a significant difference between the mean of physical performance in the two groups, and the mean of physical performance in the intervention group was significantly higher than the control group (P=0.03). Also, the mean of the physical pain dimension in the intervention group was lower than the control group (P=0.01).