Effect of ketorolac with and without acetaminophen on pain management and control after major orthopedic surgery

Abstract

Inadequate and undesirable pain control after surgery increases the risk of chronic pain. In addition, it can cause acute sleep disturbances, decreased respiratory movements, as well as cough suppression and sputum secretion. Moreover, chronic pain can cause infarct ischemic myocardial lung infection, ileus, urinary retention, thromboembolism, impaired immune function, anxiety, and secondarily leads to patient dissatisfaction, damage their confidence and prolonged hospitalization and increased costs will be. Pain control is especially important in orthopedic patients because poor pain control in them can be accompanied by delayed movement and limited joint movements. Therefore, we decided to evaluate the combination of acetaminophen with ketorolac and ketorolac alone in pain control and pain management in patients with a history of coronary artery bypass graft surgery after orthopedic surgery in patients admitted to the orthopedic ward of Imam Reza Hospital in Tabriz. let's compare. Materials and Methods: This study is a double-blind clinical trial that compares the use of ketorolac with intravenous acetaminophen or ketorolac alone in patients undergoing orthopedic major surgery. After surgery, patients were divided on the basis of a random number table and based on the number of patients admitted to the study; After surgery, patients received ketrolac or ketrolac + intravenous acetaminophen, and during the 24-hour follow-up, patients were evaluated for postoperative pain, initially at zero hour of recovery, then at 12 and 24 hours with rapid onset of the disease. VAS is done. Finally, the data were compared with t-test and Chi-square. Results: Comparison of variables between the two groups participating in the study in the sixth and twelfth hours after surgery showed that the severity of pain, need for pethidine, nausea and vomiting in the acetaminophen + cortulac group was significantly lower than the ketrolac group. Was; At other times, no significant differences were observed between the two groups.