The Effect of Oral Levothyroxine on Hemoglobin Bleeding and Hemoglobin Level During and After Surgery in Patients with a History of Heart Disease

Abstract

Considering that bleeding during pelvic joint replacement surgery can impair the positive results of surgery; Also, considering that people who are candidates for pelvic joint replacement surgery often have heart disease and bleeding in people with a history of heart disease can have adverse effects on mortality after surgery and that it may Decreased thyroid hormones during surgery are factors affecting the rate of bleeding and also the contradictory results of studies in this field. We decided to study the effect of oral levothyroxine on bleeding and hemoglobin during and after surgery. Pelvic joint replacement in patients with a history of heart disease. Materials and Methods: This study is a randomized clinical trial without blinding that was performed on 40 patients who were candidates for hip replacement surgery and a history of heart disease in Tabriz. Patients were divided into intervention and control groups. For the intervention group, at different times (from surgery and during surgery) each time 20 micrograms of levothyroxine tablets were given. In the control group, they received a placebo and the amount of hemoglobin, bleeding and the need for blood transfusion between the two groups with statistical tests. Relevant were compared. Results: The results showed that the hemoglobin level after the fourth day compared to before surgery decreased significantly (P=0.251) while the hemoglobin level in the control group significantly on the last day compared to before Decreased from surgery (P=0.021). The amount of bleeding in the control group was significantly observed at all times (P=0.033) while the amount of bleeding in the intervention group was less severe and non-significant (P=0.139); Comparison of serum intake (P=0.001), blood volume (P=0.021) and urine observed in the bladder (P=0.003) also indicated that these cases were also higher in the intervention group than The control group was significantly lower. Serum T3 level was lower in the intervention group than the control group and there were statistically significant differences between the two variables.