Prevalence of Cardiac Amyloidosis in Patients with Aortic Valve stenosis by strain echocardiography

Abstract

Systemic amyloidosis is caused by tissue infiltration by proteins and causes various clinical manifestations by involvement of organs. One of these organs is the heart. Concomitant amyloidosis in patients with severe aortic stenosis is one of the factors influencing the prognosis, possible complications and treatment measures. Concomitant amyloidosis in patients with severe aortic stenosis is one of the factors influencing the prognosis, possible complications and treatment measures. Materials and methods: After the approval of the Research Council of Tabriz University of Medical Sciences and the ethics committee of the faculty of medicine, Patients with a complete census who were diagnosed with severe aortic stenosis (aortic valve surface less than 21 cm2 and the average valve gradient is above 40 mmHg) in the desired period referred to the echocardiography department of Tabriz Civil Hospital after obtaining patient consent entered the study Were. All patients underwent trans-thoracic echocardiography by strain and classical methods, and patients with evidence of amyloidosis on echocardiography underwent 99_ Tc-DPD (Perugini grades 1 to 3) to confirm the diagnosis. For each patient, a checklist was prepared and completed including demographic information, clinical signs, echocardiographic features of the aortic valve and heart cavities, ECG interpretation, and traditional graphic results. The collected data were statistically analyzed by SPSS software. Results: Finally, after excluding patients with incomplete information in the file, 42 eligible patients were included in the final analysis of the study. Only 2 patients had amyloidosis, with a prevalence of about 4.7%. There was a higher prevalence of AF rhythm in patients with amyloidosis, but there was a significant difference between the study groups in terms of TTE findings only in EE. Cherry on Top view in strain echo was observed in 14 patients and there was a significant difference between study groups in terms of Cherry on Top view in patients's strain echo. The sensitivity of this view in the diagnosis of cardiac amyloidosis is equal to 100% and the specificity of this test is 70%. The positive predictive value of this test is equal to 14.28% and its negative predictive value is equal to 100%.