Comparison of liver elastography results in Covid- 19 patients with and without increased liver enzymes

Abstract

In some patients with Covid-19, an increase in liver function enzymes was observed, and in some cases, there was no change in enzymes. On the other hand, elastography is a non-invasive, inexpensive, and accessible modality that is highly sensitive to LS examination. Since no study has been performed in our region in this field and the contents mentioned, this study aimed to evaluate the status of liver function and its relationship with liver elastography results in patients with Covid-19. Materials and Methods: In this study, a cross-sectional study of patients with Covid-19 confirmed by PCR diagnosis was included in the study. Patients with chronic liver disease and diabetes, chronic kidney disease, and obese people (BMI above 28 kg/m2) were excluded from the study. Levels of liver function enzymes in patients two weeks after PCR positive (ALT, AST, total bilirubin, alkaline phosphatase); Measurements and patients underwent liver elastography. Liver IQR / M and liver stiffness (kPA) were measured. Patients underwent liver elastography and liver enzymes six months later. This study investigated the effect of Covid-19 disease on fatty liver and fibrosis Patients with and without elevated liver enzymes. Results: Patients were studied in two groups of 45 cases (including patients with elevated liver enzymes) and control (patients without elevated liver enzymes). Frequency of fever (60 vs. 15.5%; p = 0.001), nausea and vomiting (44.4 vs. 13.3%; p = 0.001) and diarrhea (48.9 vs. 6.7%; 001 /P =) was higher in patients in the case group. The frequency of fatty liver in patients in the case group was significantly higher than the control group (37.8 vs. 17.8%; p = 0.029), but no statistically significant difference was observed in the frequency of liver fibrosis between the two groups ( 31.1 vs. 15.6%; p = 0.067). In patients with Covid-19 with elevated

liver enzymes, the initial LS and IQR / M levels and six months after recovery are significantly higher than patients without elevated liver enzymes.