Comparing the amount of pain and incidence of dry socket with and without the use of porous gelfoam containing curcumin after the extraction of impacted wisdom teeth

Abstract

Introduction: Dry socket is one of the main problems after tooth extraction, which is more common especially after mandibular third molar surgery. Curcumin has been introduced as a plant compound with many therapeutic properties. The aim of the present study was to investigate the effect of porous gelatin gelfoam containing curcumin nanoparticles in preventing the occurrence of dry socket after wisdom tooth extraction. This study was carried out in continuation of the previous study of this group, which was the preparation and laboratory evaluation of this material. Material and methods: In this clinical trial study, 38 patients who needed surgery for two wisdom teeth (bilateral) with the same mesio angular position in the lower jaw were included in the study. After the end of the surgery, one of the two surgical sites was randomly considered as the experimental group and the other side as the control group. On the test side, an antimicrobial porous gel foam (containing curcumin nanoparticles) was placed inside the cavity. The incidence of pain, swelling, bad breath and dry mouth in the two study groups was investigated during one week after surgery. Result: The intensity of pain over time in both curcumin and control groups was significantly reduced from the first day of surgery to one week after surgery (p-value=<0.001). The intensity of pain decreased over time in the curcumin group more than the control group (p-value=0.042). Although the changes in the swelling rate of the distance from the corner of the nose to the ear hole as well as the distance from the corner of the lip to the ear hole over time were the same in both curcumin and control groups, but the swelling rate of the distance from the corner of the nose to the ear hole on the fourth and seventh day In the curcumin group, it was significantly lower than the control group (p-value=<0.023). Patients had favorable conditions in terms of bad breath, surgical site repair and clot formation. Finally, no incidence of dry skin was observed in any of the curcumin (intervention) and control groups. Conclusion: Based on the findings of the present study, the use of gelfoam containing curcumin nanoparticles can be effective in reducing the amount of pain and swelling caused by wisdom tooth extraction.