The effect of CTLA-4 inhibition on growth، migration and apoptosis of oral cancer cell line

Abstract

Oral cancer is the most common cancer in head and neck region with low survival rates. treatment options for tis malignancy include surgery, chemotherapy, radiotherapy and combination of these modalities. These treatment options have well known side effects which lower the life quality of patients with oral cancer. The aim of this study is to introduce immunotherapy as an efficient treatment method for oral cancer.in this study an immune checkpoint molecule, CTLA-4, has been targeted. CTAL-4 is a glycoprotein on cell surface which regulates immune systems response. This glycoprotein is expressed by some of the components of immune system such as T reg lymphocytes to control activated T lymphocytes responses. Some cancer cells such as oral cancer cell also express CTLA-4 on their surface to inhibit T cell activation which results in tumor progression and growth. Downregulation of CTLA-4 can be a new treatment approach with lesser side effects.