The association of Treg cells and Th17 cells development factors and Anti-TPO antibodies in RPL patients

Abstract

Due to the extensive studies performed on the process of recurrent abortion, it seems that the mechanisms of fetal rejection are similar to the rejection of other allograft tissues. Although contradictory theories have been proposed in confirming or rejecting the relationship between immunological factors and anti-thyroid antibodies and abortion, this study aimed to investigate the relationship between factors influencing the development of Treg and Th17 cells and the amount of anti-TPO antibodies in patients with abortion. It was done repeatedly.

Materials and methods: This case-control study was performed on the population of patients with recurrent miscarriage who referred to the clinic of the hospital *** and the office of the project executors in 1399. Participants in this study were divided into three groups: healthy pregnant women, anti-TPO-positive pregnant women without abortion, and anti-TPO-positive women with recurrent miscarriage. Blood sampling was performed to collect data, followed by Th17 cell count. And Treg, serum levels and expression of IL-17 and TGF-B genes and expression of Foxp3 and RORγt genes were measured.

Results: Based on the results of this study, the number of Th17 and Treg cells, serum levels and expression of IL-17 and TGF-B genes and expression of Foxp3 and RORγt genes were examined. Based on the findings of this study, Th17 and Treg cell count, serum level and IL-17 and TGF-B gene expression and Foxp3 and RORγt gene expression in healthy and anti-TPO-positive pregnant women without abortion with anti-TPO-positive women with abortion Repeated showed a significant difference so that the levels of Th17 and IL-17 in anti-TPO positive women with repeated abortions increased compared to the other two groups and other factors decreased significantly.