Comparision of Therapeutic effects of the herbal anti acne formulation (Acdine gel, Tea Tree Oil 5%) and topical clindamycin in mild acne vulgaris treatment

Abstract

Staphylococcus aureus and most gram-negative bacteria are sensitive to tea tree oil; So far, no comparative study has been done to compare the effects of these two drugs in the treatment of acne vulgaris, and given that the first line of treatment for acne is antibiotics and microbial resistance to topical topical antibiotics is gradually increasing; Therefore, in case of similar results of treatment with Acdin herbal gel containing tea tree oil and its less side effects, Acdin herbal gel can be a suitable alternative for treating mild acne. Materials and Methods: In this study, 60 patients aged 15 to 30 years with mild acne vulgaris were selected from the patients referred to the dermatology clinic of Tabriz Sinai Hospital. Children, pregnant women, patients with skin and systemic diseases involving the face were excluded from the study. 30 patients will be randomly given Acadin gel containing 5% tea tree oil and another 30 people will be given clindamycin gel 1% twice a day. The subjective history of the patient will be recorded. This study is performed as a double-blind study in which neither the doctor nor the patient knows the type of drug used. Samples are coded by the administrator. Examinations are performed every 2 weeks and the results are recorded and photographed. The duration of treatment for each patient is determined by the doctor. Results: In both groups, changes were observed to improve the disease, but both groups were effective, but the effects of clindamycin were significantly lower than the other group (P=0.014).