Effects of voluntary exercise on IL-10, IL-11 levels and NF-κB, NRF2 cross talking in lung tissue of type 2 diabetic rats

Abstract

The lung, as tissue with high density capillary networks, may be the target of capillary destruction in diabetics. Inflammatory cytokines are a risk factor for diseases such as asthma, lung cancer or chronic obstructive pulmonary disease. Given that little research has been done on lung damage from diabetes due to lack of clinical evidence and the complexity of the physiological system of the lung. In this study, we aimed to investigate the effect of voluntary exercise on TNF-α, IL-10, IL-1, NF-κB and Nrf2 levels in the lung tissue of type 2 diabetic rats. Materials and methods: In this study, 48 male Wistar rats in the weight range of 220-180 g were randomly divided into 4 groups (12 rats in each group): control (Col), diabetic (Dia), voluntary exercise and diabetic - voluntary exercise (Dia + Exe). Type 2 diabetes was induced by a high-fat diet for 4 weeks and intraperitoneal injection of streptozotocin (35 mg / kg). After confirmation of diabetes, voluntary exercise was performed for 10 weeks in a special running wheel. Finally, after anesthesia, the lung tissue was removed and the levels of IL-10, TNF-α, IL-11, NF-κB and Nrf2 were measured. Results: The findings of this study showed a significantly decreased in the levels of IL-10, IL-11, Nrf2 (p <0.001) and a significantly increased in the levels of NF-κB and TNF-α (p <0.001) of the lung tissue of diabetic groups in Comparison with the control group. Voluntary exercise improved these parameters.