Evaluating the healing effect of Ajuga chamaecistus tomentella on second grade burn wounds in patients referred to burn center

Abstract

Evaluating the Healing Effects of Ajuga chamaecistus ssp. tomentella, on Second Grade Burn Wounds, a Double-Blind Randomized Controlled Clinical Trial Abstract Background: Nowadays, the use of medicinal plants is on the rise mainly due to its fewer side effects and fewer treatment costs. Despite the traditional reports on the healing property of Ajugaspecies, no clinical studies have been conducted. In this study, the effect of hydroalcoholic extract cream of Ajugachamaecistusssp.tomentella (3%) had been compared with nitrofurazone cream (0.2%) on the second-degree burn wound healing. Materials and Methods: This clinical trial was performed at Motahhari Burns Hospital in Tehran. Fifty-two cases of second-degree burn patients were randomly assigned to two groups of 26 members, including nitrofurazone and Ajuga, and were bandaged daily. This study evaluated wounds based on the onset of epithelialization, healing time, post-drug irritation, primary irritation, decreased irritation, post-drug pain, primary pain, decreased pain,allergy, infection parameters, and the bates-jensenWound Assessment Tool. SPSS, version 20 were used for data analysis. Results: Based on the observed results, Ajuga cream was compared to nitrofurazone in cases of the mean day of epithelialization onset (P-value = 0.007), healing time (day) (P-value = 0.001), Post-drug irritation (P -value = 0.007), decreased irritation (P-value <0.001), post-drug pain (P-value = 0.018), decreased pain (P-value = 0.001) (all with P value less than 0.05); it was observed that Ajuga was more effectivethannitrofurazoneand there was a statistically significant difference between the two types of drugs. According to the results, the Ajuga cream (3%) can be a useful remedy for burn wounds due to the reduction in the onset of epithelialization, healing time, post-drug irritation, irritation reduction, post-drug pain, and pain reduction. However, further large clinical trials are needed to confirm these results.