Comparison of diagnostic Accuracy of Intraoperative Frozen Section and Touch Imprint Cytology in assessment of surgical margins in esophageal cancer surgery

Abstract

There are different methods with different diagnostic accuracy to evaluate the pathology results in different surgeries, including esophageal cancer, the results of which are different in different geographical areas according to the type of devices available. Very few studies in the world have been performed to evaluate the accuracy of frozen section and touch imprint cytology to determine the margin during esophageal cancer surgery, so in this study we decided to examine this case to confirm, the preferred method for determining the margin Surgical resection should be used during esophagectomy in esophageal cancer Materials and Methods: In this study, 100 patients with dysphagia who referred to the thoracic and surgical clinic of Imam Reza Hospital in Tabriz and were diagnosed with esophageal cancer in endoscopic and biopsy examinations and were candidates for esophagectomy, will be included in the study. For all patients, both frozen section and contact imprint cytology were performed during surgery; The two methods were compared in terms of sensitivity, specificity, predictive value and diagnostic accuracy. Results: In the study of sensitivity, specificity, positive and negative predictive value and diagnostic accuracy of the two methods studied in the present study, it was found that cytological sensitivity to frozen section is significantly better; Also, in the study of the specificity of the two methods, it was found that the specificity of the cytological method is significantly more favorable than the frozen section method; The predictive value of the cytology method was 100% correct while in the frozen section method it was 88% correct; Finally, the diagnostic accuracy of the cytology method was 98% and the diagnostic accuracy of the frozen section was 91%.