Effect of diphenhydramine and granisetron on the prevention of postoperative nausea and vomiting and pain after laparoscopic cholecystectomy

Abstract

Nausea and vomiting are unpleasant side effects after general anesthesia; This complication occurs in some surgeries with more severity and prevalence than other surgeries; Attacks of these surgeries include laparoscopic cholecystectomy; Preventive nausea and vomiting should be considered as nausea and vomiting after surgery can have side effects. Granisetron is a highly specific 5HT-3 receptor inhibitor that binds very strongly and irreversibly to 5HT-3 receptors and exerts its anti-nausea and antiemetic effects. Diphenhydramine is an antihistamine whose analgesic and antiemetic effects have already been proven. However, it is unknown whether preoperative administration of diphenhydramine improves the quality of postoperative recovery. Therefore, this study was performed to compare these two drugs. Materials and Methods: This study was a randomized double blind clinical trial that was performed during 2009-2010 with the participation of 120 patients who were candidates for elective laparoscopic cholecystectomy. Patients were randomly divided into two groups: granisetron and diphenhydramine. Prior to extubation, the patients were injected intravenously. Data were collected in SPSS Ver22 software and compared with t-test and Mann-Whitney U tests with a mean level of alpha of less than 0.05. Results: The results showed that in the recovery unit, the first hour, the second hour, the fourth hour, the sixth hour, the twelfth hour, the first day and the second day, there was not any statistically significant difference between the two groups in the severity of nausea and vomiting and both drugs have similar effects; Although granisetron may be said to work better than diphenhydramine but this advantage was not significant.