Interactions between drugs and Pacemaker and ICD in patients with arrhythmia of Shahid Madani (p) hospital of Tabriz in the year 1399

Abstract

Introduction: Permanent pacemaker (PPM) and implantable heart defibrillator (ICD) are electronic heart implant devices. PPM is used to monitor heart rate and generates a normal heartbeat by sending electrical pulses. ICD is used to further treat cardiac dysrhythmias. Aim: This study aims to investigate the Interactions between drugs and Pacemaker and ICD in patients with arrhythmia in Shahid Madani Hospital as a diagnostic and therapeutic center for cardiovascular diseases. Patients with ICD or Pacemaker are at risk for interference with some drugs so this type of study is necessary to avoid potential risks. Methods: This cross-sectional study was performed in Shahid Madani Hospital for 6 months in 2020 on patients with ICD/Pacemaker. Number of clients, which is 500 people per year, the sample size using the Cochran formula was set at 200 people. Patients who are candidates for ICD/Pacemaker were evaluated for drug interactions based on valid scientific sources. The sample form included patients' demographic information, medical and pharmacological records. Interactions in SPSS statistical software was investigated using relevant tests such as Spearman. Results: 196 eligible patients were included in this study. According to Spearman analysis, there is little correlation between ICD/PM interactions with the studied factors such as blood pressure, EF%, underlying diseases such as hypertension, ventricular atrial block and drugs like beta-blockers, digoxin, and amiodarone. Based on the data of previous studies on potentially interfering drugs with ICD/PM function, there is interference in 30 cases (15.2%) between ICD and drugs and in 15 cases (7.6%) drugs interferes with pacemaker. In general, in 32 cases (16.2%) there is an interaction between ICD/pacemaker and drugs. Conclusion: Based on This study in Shahid Madani Hospital in Tabriz, there is no serious interactions between drugs and ICD/PM clinically, but this issue needs further research.