Comparison of serum level of vitamin D in Patients with Non-alcoholic Fatty Liver Disease (NAFLD) after administration of Oral & Intramuscular Vit D

Abstract

NAFLD is a pathological condition that includes a range of liver diseases in which triglycerides are present in hepatocytes (hepatic steatosis) and can cause various complications such as liver cirrhosis. On the other hand, vitamin D is one of the most important vitamins in the body that is involved in various physiological processes. Due to the lack of studies to investigate the relationship between the type of vitamin D consumed in patients with non-alcoholic fatty liver, in this study, the relationship between oral and intramuscular vitamin D and laboratory and sonographic evaluation of patients were investigated. Materials and Methods: The present study is a clinical trial study in which 66 eligible non-alcoholic fatty liver patients referred to the gastrointestinal clinic of Tabriz University of Medical Sciences were randomly enrolled. The clinical records of these patients were reviewed and the basic information of the patients was recorded and the vitamin D levels of the patients in both study groups were measured at the beginning of the study. One group of patients was treated with oral vitamin D 50,000 units weekly for one month, and then 50,000 units monthly. In the second group of patients, 300,000 units of muscle vitamin D were placed in two units with a distance of one month. 25 levels of hydroxyvitamin D in patients in both groups; It was measured again 3 months after the start of treatment. Results: A total of 66 patients were included in the study. The mean age of patients was 50. 11 years. Of these, 33 patients (50%) were female and 33 patients (50%) were male. The mean of 25 (OH) Vitamin D was 8.62 ± 2.57 ng / mL. 33 patients (50%) were treated with oral vitamin D and 33 patients (50%) were treated with intramuscular vitamin D. The age of patients in the oral vitamin D group was 51 ± 11 years, which was not significantly different than the intera-musclar group (49 ± 10 years) (p = 0.314). 25 (OH) Vitamin D before treatment in patients in the muscle group was significantly higher than the oral vitamin D group (9.30 ± 2.25 compared to 7.94 ± 2.72 ng / mL, p = 0.021 ). The level of 25 (OH) Vitamin D in both groups was significantly increased after treatment, so that in the group of oral vitamin D was 25.5 ± 15.55 ng / mL compared to before treatment (p = 0.001) and in Injection group had 23.94 ± 15.56 ng / mL compared to before treatment (p = 0.001), there was an increase in 25 (OH) Vitamin D level. There was no significant difference between the two treatment groups in terms of post-treatment laboratory findings (including Ast, Alt, Alkp, TG, Chol, FBS, 25 (OH) Vitamin D.) (P <0.05).