Comparison of Traumastem© powder with Routine Tampon in the Treatment of Non-traumatic Epistaxis

Abstract

The aim of this study was to compare this treatment with routine topical therapy in the treatment of epitaxy in patients referred to the emergency department. Methods: This is a randomized clinical trial study. Criteria for entering the study include patients aged 18-65 years who referred to the emergency room with epistaxis. Conditions for leaving the study include coagulation disorders, patients with multiple traumas, nasal trauma, arterial bleeding, shock, and patient dissatisfaction with participating in the study were not included in the study. Patients were then divided into 2-person blocks based on a randomized computer program. Primary variables include bleeding control time and patient satisfaction. Secondary variables include no bleeding again within the first 24 hours after treatment. Finally, using a 10-digit scoring system (VAS), the patient's satisfaction with the treatment method was assessed.

Results: In this study, 107 people entered the traumastem (intervention) and 96 entered the tampon group (control). In the intervention group, 85 people (86.7%) had nosebleeds controlled and 22 people (20.6%) took more than 5 minutes or were not controlled at all, while in the control group, 85 people (88.5%) Epistaxis was monitored for less than 5 minutes and 11 people (11.5%) did not control bleeding or lasted more than 5 minutes (Pv≤0.001). In contrast, in the intervention group, only 10 person (9.3%) experienced epistaxis recurrence within the next 24 hours, while in the control group, 9 individuals (9.4%) had recurrence (Pv≤0.001). Comparing patients' satisfaction, in the intervention group, the satisfaction rate was 8 ± 1.12, which in the range of 25% -75%, this level of satisfaction is between 8 and 9, and in the control group, this amount is equal to 6 ± 1.09 in the range of 25% - 75% is equal to 6 to 7 (Pv = 0.008).