Comparing the efficacy of dexmedetomidin and ketamin infusion in reducing pain following preoperative propofol injection

Abstract

Ketamine and dexmedetomidine can be used to reduce the rate of propofol injection (PIP) injection, but the side effects of ketamine are more than dexmedetomidine. Few studies have compared the reduction in PIP between ketamine and dexmedetomidine. Due to the presence of ketamine-induced drug side effects in the patient and the fewer side effects seen in dexmedetomidine, and considering that these two drugs can reduce the pain caused by propofol injection, on the other hand, considering that this study in This study has not been done in Iran and it has been done in a limited way in the world. Materials and Methods: This randomized clinical trial study was performed with the participation of 100 patients undergoing general anesthesia in Imam Reza Hospital (Tabriz-Iran). Patients were randomly divided into two groups of control and comparison; The first group consisted of patients who received 0.5 mg / kg ketamine diluted in 20 cc of normal saline for 10 minutes and the second group received 0.5 mg / kg dexmedetomidine diluted in 20 cc normal saline over 10 minutes. Received minutes of injection. Pain in the patient was measured by McCririck and Hunter questionnaire and finally the data were entered into SPSS18 statistical software and compared with t-test and Fisher's exact test with a significance of less than 0.05. Results: The study of pain in both groups showed that the group that used dexmedetomedine to reduce pain caused by propofol injection suffered less pain than the group that used ketamine to reduce pain caused by propofol injection. These changes between the two groups were significantly less in the dexmedetomidine group than in the ketamine group (P=0.036).