Changes of lipid Profile in Sepsis Patients and its relation to the severity of the disease

Abstract

Sepsis is a major leading cause of death in the world, accounting for 26% of hospitalizations and 16% of intensive care units. The aim of this study was to determine the changes in fat profile in sepsis and its relationship with disease severity. Materials and Methods: In this cross-sectional study, 100 patients with sepsis whose diagnosis was confirmed were included in the study. 100 healthy individuals (from patients' companions) were selected as the control group. For all patients, necessary research information including: age, sex, site of infection, different levels of fat profile including apolipoprotein, triglyceride and total cholesterol, white blood cell count, length of hospital stay, need for hospitalization in intensive care unit, length Duration of hospitalization in the intensive care unit, patient outcome, was assessed. Fat profiles were checked on days 1-3-7. The correlation between the measured levels and the length of hospital stay in the patients in the study group. Results: The mean age of patients was 54.65±18.25 years and 55% of patients were male. The average number of ICU hospitalization days was 6.00±3.00. Forty percent of patients with diabetes were sweet. The most common site of infection in patients was wound infection and bed sores. No correlation was observed between patients' lipid profile and number of days of hospitalization. Cholesterol, HDL and LDL levels were lower in healthy patients than in healthy patients on the day of admission and up to 7 days after admission. Low cholesterol and high LDL were also predictors of mortality in the study