Comparison of induction with incremental versus fixed high concentration of sevoflurane in children

Abstract

Studies have been conducted to reduce the complications of using sevoflurane with high fixed dose and the importance of its use in children and lack of sufficient studies in Iran. This study aimed to compare the complications and quality of anesthesia between two methods of inducing an increase in anesthesia and with Sevoflurane high dose in children. . Materials and Methods: In this double blind clinical trial study in Tabriz Children's Hospital in 2018 and 2019, 50 patients were randomly divided into two groups: constant dose and incremental dose. The anesthetic system was filled with pop-off and end of the system by hand with 30% oxygen mixture and 70% nitrous oxide. Then with mask filled with anesthetic gases, an inhalation inhalation with a mask began and after two minutes of sevoflurane, 8% was added to the anesthetic gases; in the second group, anesthesia induction began, as in the first group, with oxygen and nitrous oxide, and after two minutes Suffolarane was added at 1% concentration, and after 1 to 2 breaths, 1% suplurane was added; after removal of the eyelid reflex, the concentration of anesthetic gas was changed to 50% oxygen and 50% Nitrous Oxide 3% Sevoflurane. To analyze the data, the squared test was used to compare the qualitative variables between the two groups and to test the means comparison such as Independent Sample's T-test and repeated measures test with considering the intermediate variables. Repeated Measuring of ANOVA for comparison Quantitative variables were used in two groups. P value less than 0.05 was considered significant. Results: The mean ± SD of depletion of the reflex in the fixed dose group in seconds was 20.8 ± 91.29 in the incremental dose group was 66.6 ± 62.8, which was statistically significant (P = 0.001). The mean ± standard deviation of LMA insertion time in the fixed dose group in seconds was 93.69 ± 12.12 in the incremental dose group of 20.5 ± 42.20 which was statistically significant (P = 0.001). The induction time for the patients in the incremental dose group was 11.7 ± 73.8255 and for the fixed dose group 90.8 ± 95.20, the results of the incremental dose group had a statistically significant difference with the dose-receiving group (P = 0.011).