Title: Evaluation of urinary level of kidney injure molecule-1 in patients with diabetes with different ranges of albuminuria

Abstract

The present study was performed to estimate and evaluate KIM-1 as a DN biomarker Materials and Methods: This study was performed on 60 patients with type 2 diabetes who were divided into three groups based on ACR (albumin to urinary creatinine) into three groups: normoalbuminuria, microalbuminuria and macroalbuminuria (ACR ˂ 30mg / g,، ACR 299-30mg / g and ACR ≥ 300 mg/g respectively). The ROC curve was analyzed to utilize the utility of urinary KIM-1 in albuminuria. Glomerular filtration rate (eGFR) was estimated. Patients and controls were monitored for fasting blood sugar, glycosylated hemoglobin (HbA1c), serum creatinine, blood urea, microalbuminuria, and KIM-1. Were classified Results: The difference between control groups and normal albuminouric, microalbuminoric and albuminoric groups was very significant for KIM-1. Positive and strong correlation between KIM-1 and microalbumin / creatinine (p˂0.001, r = 0.92), and Urinary Kim-1 levels were positively correlated with microalbuminuria, serum creatinine, BUN, duration of diabetes, and BMI. Kidney Injury Molecule-1 levels, along with urinary albumin excretion and the duration of diabetes, were found to be independent risk factors associated with low glomerular filtration rates. An inverse association was observed between urinary KIM-1 and eGFR. (P ˂ 0.001, r = - 0.7.7)