study on association of renal function and mortality and prognosis of acute ischemic stroke

Abstract

Stroke is one of the main causes of long-term disability among patients and has many emotional, social and economic consequences. In 20-40% of patients with acute ischemic stroke, neurological symptoms develop in the early hours and lead to increased mortality in these patients. Studies have reported factors that predict Early Neurological Deterioration (END), such as clinical parameters such as NIHSS (National Institutes of Health Stroke Scale), body temperature, history of diabetes, increased or decreased blood pressure, laboratory tests such as coagulation markers, inflammatory markers and serum glucose levels at hospitalization, and computed tomography (CT) findings. The severity of stroke and changes in cerebral blood flow affecting the ischemic area (ischaemic penubra) have been identified as predictors of premature deterioration. Few studies have examined the association of renal function with the prognosis and mortality due to acute ischemic stroke. The aim of our study was to evaluate renal function using urea, creatinine and glomerular filtration assays and the role of its changes in the prognosis of patients with mortality and length of hospital stay and ICU. Methods: In this cross-sectional descriptive study, patients who were admitted to Imam Reza Hospital in Tabriz with a diagnosis of ischemic stroke in 2019 were included in the study. Patients 'information such as age, sex, urea, creatinine, glomerular filtration, mortality, length of hospital stay and length of hospital stay in the ICU were extracted in accordance with the relevant ethical principles using patients' clinical records and entered in the data collection form. Results: There were 431 male patients (62.2%) and 262 female patients (37.8%). The mean ± standard deviation of patients' age was 68.97 ± 14.10 years. The mean ± standard deviation of patients' weight was 72.78 ± 12.77 kg. The mortality rate in patients was 107 (15.44%). The mean ± standard deviation of patients' urea was 39.82 ± 19.47. The mean ± standard deviation of patients' creatinine was 1.26 ± 0.94. Also, the mean ± deviation of the glomerular filtration rate was 37.5 64 64.79. According to the t-test, there was a significant relationship between urea and creatinine levels and GFR of patients with their mortality.