Evaluating the Level of Oxidatively Modified Low-Density Lipoproteins (oxLDLs) in Patients with Hematological Malignancies and its Comparison with Control Group

Abstract

oxidative low-density lipoprotein (oxLDL) is a pro-inflammatory and atrogenic factor, which embodies free radicals per se, and plays a pivotal role in atherosclerosis. Studies have shown that oxLDL and generally dyslipidemia are more prevalent in patients with different cancers. Regarding the fact that no study has evaluated the level of oxLDL in AML patients and compared it to control group, especially in the north west of Iran, this study aims at evaluating the oxLDL level in these patients and comparing them with control group. Methods: In this case-control study, 36 patients with AML and 36 control patients were chosen randomly and entered the study, in Shahid Ghazi hospital, Tabriz, Iran. After getting the informed consent forms from the patients, demographic data including age, sex, type of disease, cause of admission, and the diagnosis were gathered. Then, for all patients the levels of serum lipids an oxLDL were measured. The data were analyzed by SPSS version 22. The level of statistical significance was considered P<0.05. Results: Mean age for case group was 44.06±14.48, and 38.92±13.70 for the control group, and no significant differences were found between two groups. Comparing two groups showed no differences between two groups regarding LDL, cholesterol and triglyceride. Whereas, regarding HDL, there was a significant difference between groups, in a fashion that was significantly higher in control group. On the other hand, comparing oxLDL level between two groups showed a significant higher level in control group.