Effect of injectable mucoadhesive polymeric scaffolds containing aloe veragel,zinc and mycophenolatemofetil on oral lichen planus lesions

Abstract

Introduction: Oral lichen planus (OLP) is a chronic inflammatory disease of the oral mucosa in adults. Oral adhesive mucosal delivery method in OLP can provide enough time for drugs to be absorbed at the site of application. On the other hand, the properties of aloe vera gel, zinc and Mycophenolate Mofetil (MMF) in repairing and healing skin and oral wounds have been shown separately. The aim of this study was to evaluate the effectiveness of adhesive mucosal scaffolds containing aloe vera gel, zinc and mycophenolate mofetil in comparison with routine treatments in the treatment of OLP. Methods and Materials: This clinical trial study was performed on 12 patients with bilateral OLP, who were referred to Tabriz Dental School during 2020-2021. For 15 days, one side of the patients' mouths were treated with adhesive mucosal scaffolds containing aloe vera gel, zinc and mycophenolate mofetil (intervention group) and the other side of their mouths were treated with edcortil / triadent ointments (control group). The size of OLP lesions was measured by digital caliper and the amount of pain and burning was assessed by VAS scale for each groups and the findings were compared before and after the treatment period Results: In this study, the size of OLP lesions in each group was significantly reduced (P<0.05 in each group), and there was no significant difference between the two groups in terms of lesion size reduction (P=0.073). Also, the amount of pain and burning in each group was significantly reduced (P<0.05 in each group), and the amount of pain and burning in the group of adhesive mucosal scaffolds was significantly reduced more than the control group (P = 0.012). Conclusion: The administration of adhesive mucosal scaffolds containing aloe vera gel, zinc and mycophenolate mofetil is recommended as an effective treatment for OLP. The effect of this treatment based on the results of this study is equal to routine and market treatments.