Effect of low positive end-expiratory pressure (PEEP) on hemodynamic status in patients undergoing gynecologic laparoscopy

Abstract

The aim of this study was to evaluate the effect of low levels of positive end expiratory pressure (PEEP=5 cm H2O) on the hemodynamic status of patients undergoing gynecologic laparoscopy. Materials and Methods: In this randomized double-blind clinical trial, 80 healthy women, aged 18-60 years undergoing gynecologic laparoscopy were studied. After induction of pneumoperitoneum, in the study group (PEEP; n=40) PPV with PEEP 5 cm H2O) and in the control group (ZEEP= 0 cm H2O, n=40) PPV without PEEP during maintenance of general anesthesia was applicated. Hemodynamic variables and ventilatory parameters were measured. Results: There was significant difference in systolic (SBP), diastolic (DBP) and mean arterial (MAP) pressure measures, and end tidal CO2 pressure (ETCO2) between the groups throughout the study. After insufflation of CO2, hemodynamic changes significantly lower in the study patients. The frequency of dysrhythmia in the study group (10%) was significantly lower than the control group (32.5%) (p=0.014).