Investigating and comparing the relationship between the levels of serum fibroblast growth factor 19 with lipid and glucose profiles, anthropometric parameters and food intake in obese and normal weight subjects with and without type 2 diabetes mellitus

Abstract

Abstract Background and aims: Fibroblast growth factor 19 (FGF-19) is known as a novel metabolic regulating factor associated with improving effects on metabolic factors and reducing food intake. This study aimed to evaluate serum levels of FGF-19 in type 2 diabetic (T2DM) patients and its relationship with lipid and glycemic indices as weel as anthropometric parameters and food intake.

Materials and methods: In this study, 84 diabetic patients and 84 non-diabetic individuals were divided into two subgroups based on BMI: obese people (BMI ≥30) and normal weight participants (18.5≥BMI>25). Demographic characteristics of the study subjects were recorded and anthropometric parameters as well as serum levels of lipid and glycemic indices were measured and compared between groups.Serum FGF-19 levels were assessed by ELISA and dietary intake of individuals was examined by a food frequency questionnaire. In each group, the relationship between FGF-19 and the measured items was investigated.

Results: The mean age and BMI of the study subjects were 48.8 ± 10.8 years and 28.8 ± 5.3 kg / m2 respectively. Serum levels of FGF-19 in healthy individuals were higher than those in diabetics (250.4 ± 80.8 pg / ml vs. 245.5 ± 74.1 pg / ml), although this difference was not statistically significant (P = 0.4). The mean serum level of FGF-19 was negatively associated with some metabolic items such as BMI, LDL, TC (P <0.01), and LDL / HDL (P= 0.02) in the healthy group with normal weight. Conclusion: Based on the findings of the present study, the levels of FGF-19 were negatively correlated to BMI, LDL-c, TC and LDL / HDL in normal weight group of healthy individuals but no association was found between diabetic patients. More studies are needed to confirm these results.

Keywords: Anthropometric measurement, FGF-19, Glycemic parameters, Lipid profile, obesity, Type 2 diabetes mellitus