The diagnostic value of serum IgG By Eliza to detecting mycobacterium tuberculosis

Abstract

Tuberculosis is one of the most important health problems in the world and one of the leading causes of death and disability in developing countries and thus the timely diagnosis and treatment is critical. The aim of this study was to evaluate the sensitivity, specificity of immunoglobulin G antibodies against 16, 63and 40kDa antigens of Mycobacterium tuberculosis in patients with pulmonary tuberculosis. Method: This case-control study was performed on patients with pulmonary tuberculosis at Imam Reza Hospital,Tabriz, Iran 2016-9. After selecting the case (n = 30) and control (n = 30) subjects according to inclusion criteria, their blood samples were obtained and analyzed in the reference laboratory by standard kits for immunoglobuline G against 16, 63 and 40 kDa antigens of mycobacterium tuberculosis. Results: The mean age of the subjects was 47.07 (15.57%). The majority of participants were 46 (51.1%) women.There was no significant difference between the two groups regarding sex and age. serological examination of patients with pulmonary tuberculosis showed 25 positive result and only 4 of the control group had a positive result. Sensitivity, specificity, positive and negative predictive values of serology test were 83.3%, 86.67%, 86.20% and 87.88% respectively.