Effect of premedication with Tapentadol and Oxycodone sustain release for post operative pain control in Laparascopic cholecystectomy

Abstract

Pain after surgery is one of the acute pains that if not controlled, it causes sometimes lasting and chronic complications in the patient. Preoperativeanesthesia is a modality by reducing central neurosensitivity by initiating anti-nociceptive prophylaxis before initiating surgical pain stimulation, thus reducing postoperative pain. Considering the importance of the issue and the side effects of treatment and non-treatment of pain, the concepts of pre-empathetic and pre-ventilatory control have found their special place to achieve higher efficacy with a lower dose. This is currently used in all medical centers as a pre-treatment with a variety of analgesics, but it is still problematic in recovery and wards in the early hours of waking from pain anesthesia and the side effects of analgesics. Al is still going on. Numerous studies have examined the effects of oxycodone, pentadol, morphine and fentanyl on postoperative pain. However, no studies have compared the effects of oxycodone with tapentadol in this regard. Materials and Methods: Sixty patients with gallstones who referred to the operating room of Imam Reza Hospital for laparoscopic cholecystectomy were randomly and available if they met the inclusion criteria for a double-blind clinical trial with parallel groups after obtaining consent They entered the study consciously. Patients were divided into three groups: 20 patients in the oxycodone group, 20 patients in the tapentadol group and 20 patients in the control group. After surgery, patients were evaluated for pain intensity based on VAS and possible side effects in recovery and ward for up to 12 hours in terms of the effectiveness of drug regimens in improving and controlling pain and possible side effects from medication. In this study, P value less than 0.05 was considered significant. Results: According to the present study, 60 patients who underwent laparoscopic cholecystectomy were studied. In this study, the mean age of patients undergoing surgery was 43.51 ± 12.31 years, of which 71.6% of women were female and 28.4% were male. According to the results, patients in the control group had more pain in the first hour and 6 hours after surgery. Also, nausea, vomiting, and nausea and vomiting together were significantly higher in the slow-release oxycodone group.