Correlation between mean platelet volume and lymphocyte to neutrophil and platelet to lymphocyte ratio with lupus erythematous disease activity

Abstract

Systemic Lupus Erythematosus (SLE) is an autoimmune disease which usually is widespread between young people and women. Various clinical specification and laboratory parameters are used to monitor disease activity in which the Mean Platelet Value (MPV) has been known as one of the newest markers. In addition, Neutrophils to Lymphocytes Ratio (NLR) and Neutrophil to Platelets Ratio (PLR) is important in most autoimmune diseases. Therefore, the purpose of this study has been to determine the relation between MPV value and NLR and PLR with SLE disease activity. Method: This study has been done on 204 active lupus patients and 152 reactive patients. In this study, disease detection has been investigated by ACR index and disease activity value has been evaluated by SLEDAI index. Then, all samples were blooded for required tests to investigate cell count and measure NLR, MPV, and PLR values. Finally, the obtained results were analyzed by SPSS 18 statistical software. P-value has been considered less than 0.05. Results: lab-factors-related results in our study show that PLR, NLR, RDW and values in the test group were more than the control group and all of these differences were significant in terms of statistical (P<0.05) while, MPV and PDW indexes in the test group were less than the control group. Also, comparison of laboratory factors in two active and inactive patient’s groups show that Neutrophil, PLR, NLR, and PDW values in patients with active diseases was more than inactive patients, while MPV and RDW in inactive patients were more than active patients. Also, our study results show that most solidarity of SLEDAI with laboratory indexes was related to PLR with 34%.