Evaluating Relationship Between Insulin Resistance (Leptin to Adiponectin ratio) and Serum Vitamin D Levels in Patients with Diabetes Mellitus Type II

Abstract

Vitamin D deficiency has been known as a major problem all over the world, and it is possible that plays a major role in pathogenesis and insulin resistance in type II diabetes. One of the indices of evaluation of insulin resistance is the ration of leptin to adiponectin. Leptin and adiponectin are two of the important adipo-cytokines secreted from adipose tissue, which play a major endocrine role in the body. Aim: Studying relationship of leptin to adiponectin ratio with serum level of vitamin D in patients with type Ii diabetes. Materials and methods: In this cross sectional clinical study, forty patients with type II diabetes (twenty males and twenty females) with vitamin D deficiency were randomly selected, and their demographic and clinical specifications such as age, weight, height, BMI, fasting blood sugar, HbA1C, lipid profile, serum levels of leptin, adiponectin, and vitamin D were measured and recorded. Then, the relationships between vitamin D levels with leptin, adiponectin, and ratio of leptin to adiponectin were studied. Results: The results obtained from the study showed that there was not any significant statistical relationship between vitamin D serum levels and insulin resistance. The study also revealed that there was not any correlation between levels of vitamin D, adiponectin, insulin resistance (ratio of leptin to adiponectin) with cholesterol level and HbA1C but there is a significant relationship between vitamin D status and fasting blood sugar. Also there was a relationship between insulin resistance and BMI. There is also a significant relationship between leptin levels with BMI in a manner that with increase in leptin level, BMI also increases. But no other significant relation was observed. Conclusion: In the present study no significant relationship between serum level of vitamin D with Leptin and adiponectin levels and ratio of leptin to adiponectin (insulin resistance) was observed. Also no connection between patients' clinical parameters with vitamin D level, insulin resistance, leptin and adiponectin levels unless vitamin D level with fasting blood sugar, insulin resistance with BMI and leptin with BMI was observed.