Relationship between drug use and incidence of oral lichenoid lesions and their demographic characteristics

Abstract

introduction: Lichen planus is a chronic inflammatory disease of the skin and mucosa, the exact prevalence of which has not been reported in different communities. The clinical significance of this disease is due to the fact that oral Lichen planus is a common disease and Some types also have the potential to become malignant. Oral lichenoid reactions (contact-medication) are also a type of oral lichen planus that may be considered as a disease or an exacerbated form of oral lichen planus due to medication or use of specific dental materials. Aims: The aim of this study was to investigate the relationship between drug use and the incidence of lichenoid lesions and its demographic characteristics. materials and methods: This study was retrospective and was performed by total population sampling method in a personal office. For this purpose, among the available files, 372 patients were identified as the research sample. Information about the patient's age and sex, medications taken, types of oral lichen planus (keratotic, ulcerative, plaque-like, erythematos, reticular, vesicular), lesion location (tongue, cheek, buccal gingiva, palatal gingiva, oral mucosa, hard palate, Buccal salcus, back of lips, floor of mouth and cheeks) were extracted. The collected data were analyzed by SPSS statistical software using Chi-square method. Results: The results showed that there is a significant relationship between drug use and the type of clinical manifestations at the level of P = 0.005. In other words, the observed frequencies indicate that the percentage of ulcerative type manifestations in drug users was higher than non-drug users and the manifestations of keratotic, erythematous, reticular, vesicular types are higher in the group of non-drug lichen plans. Another finding of this study indicates that there is a significant relationship between drug use and the type of symptomatic and asymptomatic clinical manifestations at the level of P = 0.01. The frequency of symptomatic lesions is higher in people taking the drug than in those not taking the drug, and this difference is statistically significant. Finally, the findings showed that the frequency of precancerous lesions did not differ significantly between the group of drug users and non-drug users.

Conclusion. Due to the significant differences in the demographic characteristics of the lesions, such as the shape of the lesions, whether they are symptomatic or not, and the age and sex of patients in drug users and non-drug users in cases where it is possible to discontinue or change the drug assess the effect of that at the appropriate time.