Effect of intra-tracheal budesonide with surfactant in treatment of respiratory distress syndrome and prevention of bronchopulmonary dysplasia

Abstract

The aim of this study was to investigate the effects of budesonide and surfactant on the treatment of respiratory distress syndrome and the prevention of bronchopulmonary dysplasia. Materials and Methods: 128 preterm infants under 1250 g or gestational age of 26-30 weeks admitted to Tabriz Al-Zahra Hospital from 2017 to 2018 were borne and admitted with diagnosis of pulmonary distresses and surfactant injection indication, were included. In control group, the surfactant was injected by 2.5 cc/kg and in the case group, in addition to the surfactant, 0.25 mg/kg budesonide was injected. Results: In general, the complications were higher in the control group than the case group. Moreover, none of the complications were statistically significant in both case and control groups. The most commonly observed complication was septicemia with an incidence of 26 cases (21.3%). The amount of FiO2 in the case group in the four hours after treatment was significantly lower than the control group (p=0.012). In the case group, the severity of BPD decreased significantly after the intervention (p=0.046).