Comparison of clinical effectiveness of ketorolac and triamcinolone injection in moderate carpal tunnel syndrome

Abstract

Carpal tunnel syndrome is the most frequent neuropathy due to entrapment, resulting in entrapment of the median nerve in the wrist in the carpal tunnel. The main symptoms of this syndrome are pain, numbness and tingling in the thumb and forefinger, and the middle finger and the outer surface of the ring finger. Topical anti-inflammatory drugs are one of the treatments. The aim of this study was to Comparison of clinical effectiveness of ketorolac and triamcinolone injection in moderate carpal tunnel syndrome patients referred to Tabriz Madani and Imam Reza hospital. Materials and Methods: In this clinical trial study, 50 patients referred to Tabriz Madani and Imam Reza hospital with moderate CTS were randomly assigned to two groups treated with topical injection of triamcinolone 40mg and topical injection of ketorolac 30 mg. Patients were evaluated using the Boston Carpal Tunnel Syndrome Questionnaire (BCTQ), Hand Griping, and EMG-NCV before and 3 months after treatment, and the results of the two groups were compared.

Results: In both groups after treatment, the mean score of the Boston questionnaire was significantly improved compared to before the treatment in general, symptomatic and functional, as well as hand Strength.Comparing the EDX findings before and after the intervention in both groups, a significant difference was observed in SNAP LATENCY, SNAP AMPLITUDE, CMAP AMPLITUDE in the triamcinolone group and in SNAP LATENCY, SNAP AMPLITUDE, CMAP AMPLITUDE in the ketorolac group. Despite the higher percentage of changes in the triamcinolone group compared to the ketorolac group, the difference between the two groups was not statistically significant. Electrodiagnostic parameter compound motor action potential Amplitude (CMAP Amplitude) was not statistically significant in any of the two groups.