Comparison of the effect of Beracsurf with Curosurf in the treatment of respiratory distress syndrome (RDS) in preterm infants

Abstract

Introduction: Respiratory distress syndrome(RDS) is the most common disease among premature infants due to lack of pulmonary development and consequent surfactant deficiency.Exogenous surfactant is very important in the treatment of this disorder.Therefore, two common types of surfactants used in the treatment of RDS were investigated. Aim: Comparison of the effectiveness of beractant and poractant alfa surfactants in the treatment of respiratory distress syndrome (RDS) in preterm infants. Method: This study is a randomized clinical trial that was performed for 8 months on 200 premature infants with RDS admitted to the NICU ward of Alzahra Hospital in Tabriz.These infants were randomly divided into 2 groups.One group received beractant at a dose of 4cc⁄kg every 6 hours and the other group received curosurf at a dose of 2.5cc⁄kg every 12 hours.All demographic information and data related to patients` treatment process were collected based on the clinical records of patients.Data were analyzed using SPSS software. Results: During this study,most infants in both groups were boys,which was considered a risk factor according to studies.Also,although corticosteroid intake was higher in the Curosurf group than in the Beracsurf group, the mortality rate due to RDS and the need for ventilation were not significantly different in the two groups, while the final fio2 rate and length of hospital stay were lower in the beractant group. Conclusion: According to the result of study, the administration of beractant, like curosurf, has beneficial effects in the treatment of RDS, and even in some cases, beractant better than curosurf can be useful in the treatment of RDS in premature infants.Considering that beractant is an Iranian brand of exogenous surfactant and in this respect it is more available than curosurf,Therefore it is suggested that this Iranian brand be used in the treatment of infants with RDS.