Insulin resistance and cachexia development in patients with metastatic upper gastrointestinal cancer

Abstract

One of the main causes of cachexia in cancer is systemic inflammation in cancer, which causes the production of inflammatory cytokines. These cytokines cause anorexia, lipolysis and muscle destruction. The importance of nutrition is so great that having a basic knowledge of nutrition management is essential for all professionals to improve patients and have a better quality of life. Therefore, it seems important to study nutritional deficiencies and increase the survival of cancer patients. Aim. investigate insulin resistance and cachexia in patients with metastatic gastrointestinal cancers. Experimental: Sixty patients who were diagnosed with metastatic GI cancer were admitted to the clinic. Insulin resistance was assessed by HOMA IR for three months. In addition, biochemical markers such as albumin and cholesterol were measured. Antiprometric specifications such as BMI, Skin fold thickness, and arm circumference were also measured using a caliper and tape measure. All criteria were measured in Baseline, the third month. Results: In the case of PEW in the third month, there was a significant relationship with mean weight every three months, skinfold and arm circumference every three months, quality of life in the first and third months, albumin in every three months and serum creatinine in the third month. In the study of the relationship between biochemical and anthropometric variables with cachexia, weight and percentage of fat, arm circumference, albumin content every three months had a significant relationship with cachexia in the second month, but abdominal circumference only in the first month and cholesterol in the second month with cachexia There was a significant relationship. Quality of life in the third month had only a significant relationship. Conclusion: The results did not show a significant relationship between death outcome and insulin resistance. Also, gender, chemotherapy regimen, age and metastasis area were not associated with insulin resistance.