Evaluation of drug interactions in newborns admitted to al-Zahra hospital from April 2018 to September 2018
Abstract
Drug interference as one of the most important subsets of drug errors can lead to unwanted reactions in patients. Drug Interactions occur when the effects or toxicity of a drug are affected by another drug.
Aim.
Evaluation of drug interactions in newborns admitted to al-Zahra hospital from April 2018 to September 2018
Experimental:
The study was based on the case of infants admitted to hospital. In the questionnaire that was designed, the information about the patients and all the drugs contained in the patient's card was recorded and recorded during the patient's hospital stay. Any medication prescribed at any time during the patient's hospitalization period was recorded and recorded regardless of the dose or dose changes when prescribing the drug or the specific reason for prescribing (whether specific, pre-emptive or pre-emptive).
Results:
In this study, 100 infants were examined. The average age of infants admitted 2.32±1.69 weeks. Of the 100 patients studied, there were no drug interactions in the orders of 38 patients, and 78 drug interactions were found in the orders of 62patients. Out of 412 drug prescriptions, 78 cases (18.9%) were drug interactions. The average daily dose for each infant is 5.65 ± 3.01 وand the average drug dose for each infant is 1.06 ± 0.89 on average. The most common cause of hospitalization was preeclampsia and then respiratory distress, which was treated with medication. According to the results, the most common drugs that cause drug interactions were vancomycin and amikacin, respectively, which were reported above 30%.
Conclusion:
The most common cause of drug interactions in children is uncontrolled use of antibiotics. Also, the most common type of drug interaction is type C, which requires monitoring during drug administration and serum drug concentration. In this study, a significant relationship was found between the number of drugs prescribed and drug interactions.