The study of efficacy of memantin on neuropathy in diabetic patients-single blind randomized ‎clinical trial

Abstract

Introduction: Diabetes is one of the most common endocrine disorders and ‎diabetic neuropathy is one of the microvascular complications in chronic diabetes. ‎Diabetic neuropathy can lead to impaired quality of life. Common symptoms of neuropathy ‎include pain, tingling, numbness, burning, and electric shock .‎ Purpose: Study the effect of Memantine on diabetic neuropathy (DN).‎ Methods: This study was a single-blind randomized clinical trial performed as a ‎pilot on 100 patients with DN between the ages of 18 and 75 years for 8 weeks. ‎Patients were randomly assigned to one of the two test and control groups. The ‎study period was 8 weeks,To monitor patients, the DN4 questionnaire and Tests ‎to diagnose and evaluate the extent of neuropathy was completed in the two ‎stages before the start of treatment and at the end of the study. Patients in the test group received memantine (first dose of 5 mg twice ‎daily for the first week and 10 mg twice daily for the next week until the end of ‎the eighth week) and patients in the control group, They received gabapentin (at a ‎dose of 300 mg 1 daily)‎ The DN4 questionnaire was used to monitor patients in 2 stages of the study, ie ‎before the start of the study and at the end of the study Results: Based on the data obtained from the score variable of the questionnaire ‎‎(Score) in the control and test group, it was ‎determined that the administration of memantine in the test group showed a ‎significant difference in the score of the questionnaire before and at the end of the Study. Conclusion: Administration of memantine in patients with diabetic neuropathy ‎has been more effective in reducing the severity of neuropathic pain.‎