Evaluation of the relation between Serum and saliva levels of urea and glucose in healthy referred patients to Tabriz Dentistry Faculty

Abstract

Introduction: The use of salivary compounds due to non-invasive has provided a suitable tool for the replacement of blood components. Due to the importance of Urea and glucose levels in many biological processes, this study evaluated the serum and saliva levels of Urea and glucose in healthy referred patients to Tabriz Dentistry Fac-ulty.

Methods: This descriptive study was conducted on 40 patients referring to Tabriz Dental School. Samples of saliva and serum of these patients were extracted accord-ing to standard protocols of erom and salivary. Data were presented mean (±standard deviation) and frequency (percentages) for quantitative and qualitative variables, re-spectively. Statistical anal-ysis was performed by SPSS24 software. To determine the correlation between se-rum and salivary levels of biomarkers was performed Pearson test by SPSS 24 soft-ware. The significance level of P <0.05 was considered.

Results: From 40 subjects we studied were 24 women and 16 men. The average ob-tained for salivary Urea was (40.6 mg/dl) , which was higher than the average of se-rum Urea (28.8 mg/dl ),and on the contrary , and the average of salivary glucose was (3.6 mg/dl) ,which was less than the average serum glucose (86 mg/dl) .The result of paired samples T test ( p-value<0.05) showed that there is a statistically significant difference between the mean of serum Urea and salivary Urea, as well as between the serum glucose and salivary glucose. Pearson correlation test results showed that there is significant correlation between serum Urea and salivary Urea (p-value<0.05), but there is a positive correlation be-tween serum glucose and salivary glucose (p-value<0.001) The salivary Urea was higher than it in serum but it was the opposite about glucose. {mean salivary Urea 40.6 mg/dl - mean serum Urea 28.8 mg/dl –mean salivary glu-cose 3.6 mg/dl – mean serum glucose 86 mg/dl }

Conclusion: It is important to measure accurately the blood factors with conservative methods in this study found that there was a statistical relationship between salivary urea and glucose and blood of healthy individuals. In the future, salivary samples can be used to measure glucose in these individuals.