Relationship between the outcome of critically ill pediatric multiple trauma patients and serum lactate level

Abstract

Objective: To investigate the relationship between serum lactate level in critically ill children with trauma and hospital mortality Materials and Methods: This study will be a longitudinal (prospective) study among infants and traumatic children. Implementation: Martyrs and Imam Reza (AS) -Tabriz hospitals are among referral and trauma hospitals in East Azarbaijan province. The study began with recruitment of all traumatic infants and children by measuring serum lactate (venous sample) at admission to the emergency department, trauma ward, and 24 hours later. And the final status of the injured child will be determined by the state of discharge including death, recovery, and complications (recovery with disabilities). The study population included all infants and children with traumatic injury. In order to control confounding factors in the design phase of the study, controlling for confounding factors was controlled. Determination of serum lactate level (infant sample) of infants and children with short-term survival status among patients with trauma began. And the final status of the injured children was determined based on the status of discharge including death, recovery and complications. Determination of serum lactate level in infants and children with short-term survival status among patients with inclusion criteria from emergency departments of Tabriz Imam Reza and Shohada hospitals in 1397 in all infants and children under 14 years. Complicating the situation are patients who have functional limitations or disability in one of the organs at the time of discharge.

Results: Out of 110 pediatric patients admitted to hospital, 10 (9%) died in hospital. Mean lactate level in critically ill patients was 3.2 mmol / l. 85 patients (77.2%) had level patients. Blood lactate levels were above 2 mmol / l. The initial level of blood lactate concentration was directly correlated with mortality. (odds ratio [OR] =; 95% confidence interval [CI], which confirms this relationship even after adjusting for variables and examining age and sex of trauma according to the PRISM table ((OR = 1.27; p < Multiple regression study showed high blood lactate level (OR = 1.17; 95% CI, 1.07-1.29; p = 0.001), high score of PRISM table OR = 1.15; 95% CI, 1.11-1.20; p < And low serum albumin level (OR = 0.92; 95% CI, 0.88-0.96; p <0.001) as independent risk factors for mortality in traumatic patients in children. Blood lactate levels associated with allergy 61% and 86% specificity as an important predictor of mortality in patients with cut-offs 5. 55 mmol / L