The Effect of Topical Application of Aloe Vera Gel on IL-1B, IL-17 of Crevicular Fluid in patients with chronic Periodontitis

Abstract

Introduction Cytokines play an important role in the pathogenesis of periodontal diseases. Alvora improves periodontal disease through its anti-inflammatory and antibacterial effect. The aim of this study was to evaluate the effect of topical application of Alvora gel on IL-1B, IL-17 of crevicular fluid in patients with chronic periodontitis Materials and methods In this two-blind clinical trial study, 14 patients with moderate to severe chronic periodontitis were enrolled. All patients enrolled in the study received non-surgical treatment. On the first day, before SRP, clinical parameters (PI), (GI), (PD), (CAL) and BOP were evaluated in both groups at four dental surfaces. All measurements were performed by an examiner who was blind to the type of treatment. Then, SRP was performed for all teeth. For each patient, the oral area was randomly divided into two groups (case and control). After SRP treatment, in the control group distilled water and in the case group, Alvora gel was injected into the periodontal envelope. 30 days after treatment, periodontal indices were measured. Saliva samples were collected before and after treatment. Interleukin levels were measured using ELISA kit. The results were analyzed by SPSS 20 software and paired sample t-test. Results After treatment, periodontitis indices (PI, GI, PD ,CAL and BOP) were improved in both groups. There was a significant decrease in IL-1B and IL-17 levels in both groups (p <.05). After treatment, the levels of interleukins in Aloe vera gel (57.04 16 16.26: IL-17 and IL-1B 06.06 10 10.99) were significantly lower than in the control group (81.33 16 16.6: IL-17 and IL-1B were 78/61/14/54 (p <.05). Conclusion Aloe vera gel reduces interleukins IL-1B, IL-17 crevicular fluid in patients with chronic periodontitis.