Effect of intravenous dexmedetomidine on control of blood pressure after laparotomy surgery in hypertensive patients

Abstract

Control of hemodynamic parameters and decrease blood loss in major orthopedic procedures are of great anesthetic concerns which can reduce perioperative cardiovascular complications and moreover decrease the incidence of blood transfusion and consequently the related complications such as hemolysis, infection, non-hemolytic reaction and pulmonary side effects. The aim of our study is to determine dexmedtomidine effects on pain, agitation and hemodynamic parameters and in patients under laparotomy surgeries.

Methods & Materials: In a clinical trial study, 82 hupertensive patients between 18 to 90 years, ASA class I, II undergoing general anesthesia for surgery of femoral shaft fracture were assessed. Protocol of general anesthesia and postoperative pain control for all patients was the same. In Dexmedetomidine group, 0.5 μg/kg/hr of Dexmedetomidine was infused during the time of operation and in control group, 5ml normal saline by the same manner of case group was infused.

Results: Trend of the change in systolic and diastolic blood pressure was statistically significant different between two groups (P<0.05). A significant decrease of pulse rate after the surgery was detected (P<0.05) but the trend of change in the pain after was not statistically significant (P>0.05). agitation in Dexmedetomidine group was significantly less than control one (p<0.05).