Comparison Study of Combination of Cryotherapy & Intralesional Injective and Multipuncture of Bleomycin vs Cryotherapy in Resistant Palmaplanter Warts

Abstract

The aim of this study was to compare the effect of combination cryotherapy and intra lesion bleomycin injection with cryotherapy in the treatment of resistant wart. Methods: Sixty patients with resistant warts were selected and randomly divided into two groups of 30 A and B patients. In each group, cryotherapy was performed three sessions during 0, 3rd and 6th weeks in case of visible lesions. In group B, in addition to cryotherapy in week 0, and in the presence of visible lesions during week 3, injections of intra-lesions of bleomycin 1 unit/ml was performed. Treatment outcomes and possible complications were evaluated during the 3rd and 6th weeks. Results: In group A, 30 patients and 234 warts were treated with cryotherapy and in group B, 30 patients and 243 resistant warts were treated with combination therapy of cryotherapy and intra-lesions injection of bleomycin. Response rate after 3 weeks of treatment for the physician in group A was poor: 11 patients (16.7%), moderate: 16 (53.3%), good: 3 patients (10%) and in group B was weak: 5 patients (16.7%), moderate: 15 patients (50%), good: 10 patients (33.3%). Response rate after 6 weeks for physician in group A was poor: 10 (33.3%), moderate: 12 (40%), good: 8 patients (26.7%) and in group B was weak: 2 patients (6.7%), moderate: 12 patients (40%), well: 16 (53.3%) patients.