Evaluation Frequency of APOL1 Gene's Variations (G1 and G2) in ESRD Patients residing in northwest of Iran

Abstract

This study examines the existence and frequency of G1 and G2 alleles of the APO L1 gene in Tabriz ESRD patients. Materials and Methods: In a descriptive cross-sectional study, 200 chronic hemodialysis patients from Tabriz were studied. Demographic characteristics of patients including age, sex, underlying disease, duration of dialysis, systolic and diastolic blood pressure of each patient, and biochemical characteristics including blood and fat profile of patients were collected according to their latest tests. The DNA extracted from the blood of the patients was examined for G1 and G2 alleles of the APO L1 gene. Results: Of 200 non-diabetic hemodialysis patients under study, 142 men (71%) and 58 women (29%) were respectively. The mean age of the patients was 58.1 ± 16 years and the range of the patients was from 20 to 79 years. The median duration of dialysis was 36 months (less than 1 month and maximum 264 months). In 200 non-diabetic ESRD patients studied in this study, none of the mutations G1 and G2 of the APO L1 gene were found.