Evaluation of Thyroid function profile in patients with major depressive disorder

Abstract

The purpose of this study was to determine the thyroid function profile in patients with major depressive disorder. Materials and Methods: For all patients with entry criteria, if completed, the Hamilton Depression inventory was filled in at the first visit, which would determine the severity of depression. At the same time, TSH, Free T4 and anti TPO tests were requested, all performed as a fasting blood sample from an environmental vein and in a single laboratory (under the supervision of the university). On the other hand, the relationship between the reported hormonal head and severity of depression (Pearson correlation) was also investigated. Results: In this study, 100 patients with major depression were evaluated. The mean ± standard deviation of the patients' age was 35.38±9.39 years. 29 cases (29%) were males and 71 cases (71%) were females. Mean ± standard deviation of TSH values in all patients was 2.80 ± 2.35 mIU/L; mean±SD of FT4 values in all patients was 14.21±3.35 pmol/L; and mean±SD of anti-TPO values in all patients, 46.46±70.84 IU/mL was. Mean ± SD for severity of depression at the beginning of the visit was 20.32±5.49 and after the 4 weeks of treatment, it was 8.69 ± 5.27 which was significantly decreased (p=0.001). There was a significant correlation between severity of depression and TSH and FT4, direct correlation and anti-TPO.