Study the serum level of melatonin and 8-hydroxy-2-deoxyguanosine in osteoarthritis patients

Abstract

The aim of this study was to investigate the relationship between the serum level of melatonin, 8-hydroxy-2-deoxy guanosine, and vitamin-D in patients with osteoarthritis (OA). Methods: This study included 47 patients with OA and 40 healthy controls. Serum levels of melatonin and 8-hydroxy-2-deoxy guanosine (8-OH-dG) were measured. In addition, the serum level of biomarkers of bone turnover such as calcium total, phosphorous, vitamin D, and alkaline phosphatase (ALP) was measured in OA patients and controls. Results: Serum level of melatonin was significantly lower in OA patients than the controls (6.18±2.25 vs. 11.57±3.87 ng/ml, p<0.05). In contrast, the serum level of 8-OH-dG was significantly increased in OA patients, as compared to controls (65.21±16.12 vs. 22.51±5.3 ng/ml, p<0.001). There was a negative correlation between serum melatonin and 8-OHdG levels in OA patients (p<0.001). We found decreased calcium and vitamin D levels, and increased phosphor and ALP levels in OA patients in comparison with controls (p<0.05).