Effect of non-surgical periodontal therapy on serum ferritin levels in postmenopausal women with chronic periodontitis

Abstract

Background: Ferritin also plays an important role in host immune response. An increased immune response augments the migration of ferritin from the plasma to within the cells to counter infective agents that attempt to bind iron from the host tissue. Two key factors that can regulate ferritin expression are iron and pro-inflammatory cytokines. Ferritin has been shown to be a positive acute phase protein in inflammation and chronic infections, including chronic periodontitis, which is followed by periodontal treatment. The serum level of this index is reduced, so the aim of this study was to evaluate the serum ferritin level in postmenopausal women following non-surgical treatment Periodontal was done. Methods : 38 postmenopausal women with chronic periodontitis were selected.Before any treatment, blood sample was taken, they were poured into a sterile tube without anticoagulant, to evaluate serum ferritin levels.Then, other clinical parameters were measured. Non-surgical periodontal treatment included oral hygiene instruction and scaling and root planning (SRP)and Prescribing two weeks of chlorhexidine0/12 % mouthwash for patients with CP. Patients were recalled 3 months post-therapy and follow up to resample venous blood and to record clinical measures. Results: The results of data analysis showed that the serum ferritin levels, PD, CAL, and BOP were measured on six sites (mesial, median, and distal points at buccal and palatal aspects) around each tooth, gingival index (GI), plaque index (PI),after non-surgical treatment, decreased significantly before treatment. Conclusion: Regarding the results obtained from the study data and comparing them with the results of other studies, it can be concluded that non-surgical periodontal treatment significantly reduces serum ferritin levels in postmenopausal women with chronic periodontitis