Effect of Intraoperative Intravenous Tranexamic Acid on Blood Loss Volume in Femoral Fracture Surgery

Abstract

In major operations, like femoral surgery due to extensive surgical field, we may have severe bleeding and massive transfusion. In this study, we aimed to evaluate the effect of tranexemic acid on reduction of bleeding and transfusion in femoral shaft surgery. Materials and Methods: After obtaining informed consent, 60 candidates of femoral shaft surgery aged 24-83 years, were entered a double blind prospective clinical trial. In the transxamic acid group, 10 mg / kg of Tronaxic Acid and infusion of 1 mg / kg /hr until the end of the operation was performed 15 minutes before surgery. In the control group, normal saline with equal volume as a drug was used at the same time in the study group. The rate of bleeding, blood transfusion, urine output, platelet count, hemoglobin, hematocrit, PT, urea, fibrinogen, INR test, PTT and creatine, and finally, patient satisfaction were measured and recorded in both groups. Results: There was no significant difference between the two groups in age and sex. Mean blood loss and transfusion requirement in tranexemic acid group was significantly less than the control group (P < 0.001). Platelet, hemoglobin, hematocrit and fibrinogen levels were significantly higher in the tranxactic group than in the control group (P <0.05). PT, PTT and urea were significantly lower in the tranxactic group than the control group (p <0.05).