The Effect of Intramuscular Hyoscine and Hyoscine-Promethazine on the Duration of Labor and Delivery Outcomes to Nulliparous Pregnant Women (Triple-Blind Randomize Control Trial)

Abstract

Abstract: The effect of intramuscular Hyoscine and Hyoscine-Promethazine on the duration of labor and delivery outcomes in nulliparous pregnant women (triple-blind randomized controlled trial)

Background & Purpose: improvement of maternal healthiness and decreasing maternal mortality and morbidity is one of important anxieties in the world. One of the factors that influences intensity of pain is duration of labor. In other words, increasing intensity of pain affects duration of labor. This study surveis the effect of intramuscular Hyoscine and Hyoscine-Promethazine on the duration of labor in nulliparous pregnant women.

Materials & Methods: this study was three blind clinical trial on 213 nulliparous pregnant women who has referred to Amiralmomenin hospital in Zanjan. Selection of samples was random and done with Rand List software and used 3,6 (1:1:1) of blocking size. This study had 3 groups. First group received 20 mg Hyoscine(A), second group 20mg Hyoscine and 25mg Promethazine(B) and third group 3cc sterile water(C). Data collection tools were including of a demographic questionnaire, checklist of data and Partograph chart. Analysis of data done by SPSS (ver16) and Anova (tukey) and chi-square test.

Results: means active phaze of labor in Hyoscine group was 88.95±51.07 min ,Hyoscine-Promethazine 100.05±65.88 min and control group 170.37±106.87 min(SD). there is significant correlation between A,C and B,C groups(p<0.001). second stage means in group A was 46.37±44.60, group B 32.25±17.74 and control group 55.05±44.44 and significant relationship was between B,C groups(p=0.03) . In third stage, there was no significant difference between groups (p=0.105). Maternal outcomes in “type of delivery” were significantly different between groups (p=0.01). There were no differences in the other maternal outcomes and fetal-neonatal outcomes between groups.

Conclusion: Findings showed that both Hyoscine and Hyoscine-Prometazine are effective in reducing the length of labor. Thus both of these drugs can be used in reducing the length of labor.