Effects of systemic melatonin and non surgical periodontal therapy on serum ferritin in patients with periodontitis disease

Abstract

Introduction: Ferritin is known as an acute phase protein in inflammation and autoimmune disorders, and chronic infection and liver disease. Studies have shown that serum ferritin levels increase in patients with chronic periodontitis. Therefore, in this study, the effect of melatonin consumption on serum ferritin levels in patients with periodontitis was first evaluated. Materials and Methods: In this randomized clinical trial study, 42 subjects (21 controls, 21 treated with melatonin) were selected from among the periodontal students of the Faculty of Dentistry of Tabriz University of Medical Sciences who had entry into the study. In order to evaluate the general condition of oral periodontal, PD (pocket depth) and joint loss (CAL) in 6 areas of each tooth, except for the third molar before and after the intervention, were recorded. The plaque index (PI) was also recorded by an examiner and hand-held UNC-15 probes. Also, in order to measure serum ferritin levels was used to ELISA kit. Finally, statistical analysis was performed using SPSS17 software and P <0.05 was considered. Results: The mean serum ferritin level in the control group before (108.55 ± 25.66) and after the mouthwash (101.15 ± 22.84) in the control group was decreased. In the intervention group, the mean of ferritin (107.25±70.03) and after intervention was decreased (95.20± 22.71).Comparison of the difference between the amount of ferritin before and after intervention in each of the groups showed that this difference was statistically significant in both groups (P-value <0.001). Also, the comparison of GBI, PD, and CAL indices between the two groups (with melatonin, without melatonin) showed that the values of these indices were significantly different between zero and after three months (P <0.05). Discussion: The results of this study suggest that the use of melatonin can be considered as an secondary treatment.